To prevent spurious transcription from a gene, acetylation of histones-which is carried out by histone acetyl transferases ahead of a moving RNA polymerase II-is quickly reversed by histone deacetylases and histone methyl transferases in the wake of the polymerase, leaving a trail of specific methylated histones. Which of the following curves do you think better represents the distribution of this specific histone methylation mark with respect to a gene?
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