Indicate true (T) and false (F) statements below regarding the folding of proteins upon their synthesis. Your answer would be a five-letter string composed of letters T and F only, e.g. TFFFF.
( ) A globular protein can fold to its native form while still within the ribosome.
( ) A protein can begin to fold and to bind to other proteins while still being synthesized on the ribosome.
( ) A protein may undergo several cycles of hsp70 binding and release while still being synthesized on the ribosome.
( ) A molten globule can form only after the synthesis of the protein is complete.
( ) A protein typically undergoes hsp60-assisted folding while still being synthesized.

Question

Indicate true (T) and false (F) statements below regarding the folding of proteins upon their synthesis. Your answer would be a five-letter string composed of letters T and F only, e.g. TFFFF.
( )	A globular protein can fold to its native form while still within the ribosome.
( )	A protein can begin to fold and to bind to other proteins while still being synthesized on the ribosome.
( )	A protein may undergo several cycles of hsp70 binding and release while still being synthesized on the ribosome.
( )	A molten globule can form only after the synthesis of the protein is complete.
( ) A protein typically undergoes hsp60-assisted folding while still being synthesized.

Quizplus · Accepted Answer

Proteins can start folding as soon as they emerge from the ribosome (or even within the exit tunnel of the ribosome, but only for small helical segments) and one domain can be fully folded and functional before an entire multidomain protein is completely synthesized. However, folding within the hsp60 chaperonin complex typically happens only post-translationally.

Indicate True (T) and False (F) Statements Below Regarding the Folding