How many ATP molecules must be hydrolyzed by the proteasome for the digestion of a protein that has been tagged for degradation with a polyubiquitin chain?
A) None; the digestion does not require ATP hydrolysis and is exergonic
B) One
C) Two
D) Ten
E) Many; the number depends on the specific protein

Question

Quizplus · Accepted Answer

The AAA proteins in the cap hydrolyze tens or hundreds of ATP molecules to unfold and thread each protein into the central 20S digestive core.

How Many ATP Molecules Must Be Hydrolyzed by the Proteasome