Switch proteins that bind and hydrolyze GTP are ubiquitous cell regulators in a wide variety of molecular processes. Which of the following statements is NOT true regarding these proteins?
A) EF-Tu is an example of such proteins.
B) GTP hydrolysis by the GTPase generally renders it inactive.
C) Activation of the GTPase involves addition of a phosphate group to its bound guanine nucleotide.
D) Guanine nucleotide exchange factors generally activate the GTPases.
E) Guanine nucleotide exchange factors accelerate the release of bound GDP from the GTPases.

Question

Quizplus · Accepted Answer

Activation of the GTPases involves exchange of a bound GDP for GTP, rather than direct phosphorylation of the bound GDP.

Switch Proteins That Bind and Hydrolyze GTP Are Ubiquitous Cell