A clinical experiment is conducted in which one group of subjects is given 20 grams of glucose intravenously and another group is given 20 grams of glucose orally. Which of the following factors can explain why the oral glucose load is cleared from the blood at a faster rate than the intravenous glucose load?
A)Cholecystokinin-induced insulin release
B)Cholecystokinin-induced vasoactive intestinal peptide release
C)Glucose-dependent insulinotropic peptide-induced glucagon release
D)Glucose-dependent insulinotropic peptide-induced insulin release
E)Vasoactive intestinal peptide-induced cholecystokinin release

Question

Quizplus · Accepted Answer

Glucose-dependent insulinotropic peptide (GIP) is secreted from the intestines in response to oral glucose intake, and it stimulates insulin secretion from pancreatic beta cells. This rapid increase in insulin secretion enhances glucose uptake into tissues and reduces blood glucose levels. This effect is not observed when glucose is given intravenously because intravenous glucose bypasses the normal physiological mechanisms in the intestine that are involved in GIP release. Therefore, the oral glucose load is cleared from the blood at a faster rate than the intravenous glucose load due to the rapid insulin response induced by GIP.

A Clinical Experiment Is Conducted in Which One Group of Subjects