In DNA replication in E. coli, the enzyme primase is used to attach a 5 to 10 base ribonucleotide strand complementary to the parental DNA strand. The RNA strand serves as a starting point for the DNA polymerase that replicates the DNA. If a mutation occurred in the primase gene, which of the following results would you expect?
A) Replication would only occur on the leading strand.
B) Replication would only occur on the lagging strand.
C) Replication would not occur on either the leading or lagging strand.
D) Replication would not be affected as the enzyme primase in involved with RNA synthesis.

Question

Quizplus · Accepted Answer

Primase synthesizes RNA primers necessary for both leading and lagging strand DNA synthesis. A mutation in primase would impair the initiation of DNA replication on both strands.

In DNA Replication in E