Which of the following describes the most likely effect that a single base substitution in the middle of gene's sequence will have on the protein the gene encodes?
A) A single amino acid would change because pairing of mRNA and tRNA in the ribosome would change.
B) The protein would be shorter because the correct tRNA would not be able to interact with the ribosome.
C) All amino acids following the substitution would be affected because the reading frame would be altered.
D) There would be no change because the genetic code is ambiguous.

Question

Quizplus · Accepted Answer

A single base substitution typically results in a missense mutation, where one amino acid in the protein sequence is changed. This occurs because the change in the DNA sequence leads to a different mRNA codon, which then pairs with a different tRNA during translation in the ribosome.

Which of the Following Describes the Most Likely Effect That