Which of the following is the most likely phenotypes of a yeast mutant that contains histones that are resistant to acetylation?
A) The mutant will grow rapidly.
B) The mutant will require galactose for growth.
C) The mutant will show decreased levels of gene expression.
D) The mutant will show increased levels of gene expression.

Question

Quizplus · Accepted Answer

Histone acetylation is associated with transcriptional activation by loosening the DNA-histone interaction, allowing transcription factors easier access to DNA. If histones are resistant to acetylation, this would likely result in tighter DNA-histone interactions, making it harder for transcription machinery to access DNA, thus leading to decreased levels of gene expression.

Which of the Following Is the Most Likely Phenotypes of a Yeast