Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. Hemoglobin Lepore is a form of hemoglobin that is missing a series of amino acids. If this form was caused by unequal crossing over, which of the following is the most likely consequence?
A) There should also be individuals whose hemoglobin contains a tandem repeat of the amino acid sequence that was deleted in hemoglobin Lepore.
B) Each of the genes in the hemoglobin gene family must show the same deletion.
C) The gene with the deletion must have undergone exon shuffling.
D) The deleted region must be located in a different area of the individual's genome.

Question

Quizplus · Accepted Answer

Unequal crossing over results in one chromosome with a deletion and another with a duplication of the same sequence. Therefore, if hemoglobin Lepore is missing a series of amino acids due to unequal crossing over, it is likely that there are also individuals with a duplication of the amino acid sequence that was deleted, leading to a tandem repeat in their hemoglobin.

Unequal Crossing Over During Prophase I Can Result in One