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Question 11

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Use the following information to answer the question.
Poliovirus is an RNA virus of the picornavirus group, which uses its RNA as mRNA. The RNA genome has a 5′ RNA cap instead of a 5′ methyl-G cap. This is followed by a non-translated leader sequence and then a single long protein-coding region (~7,000 nucleotides) followed by a poly-A tail. Infected cells were incubated with radioactive amino acids and viral proteins were isolated. After a short incubation with radioactive amino acids only very long viral proteins were seen, while longer periods of labeling result in several short polypeptides of different lengths.
Which of the following conclusions is most consistent with the results described?


A) Host cell ribosomes translate the viral coding region and poly-A tail at different times resulting in the different populations of proteins.
B) The RNA is first translated into a single long protein, which is then cleaved into shorter ones.
C) The RNA is translated into short polypeptides, which are then assembled into large complexes.
D) The large radioactive polypeptides are coded by the host, whereas the short ones are coded for by the virus.

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