A loss of function of Apaf1, the human homologue of ced-4 in nematodes, is most likely to result in which of the following?
A) activation of a developmental pathway found in the nematode but not in humans
B) a form of cancer in which normal apoptosis fails
C) excess activation of the human analog of the ced-3 protease
D) extensive tissue damage due to excess apoptosis

Question

Quizplus · Accepted Answer

Apaf1 is involved in the apoptotic pathway, and its loss of function can lead to impaired apoptosis. This can result in cells that should be programmed to die surviving instead, potentially leading to cancer due to the accumulation of abnormal cells.

A Loss of Function of Apaf1, the Human Homologue of Ced-4