In disseminated intravascular coagulation (DIC),what activates the coagulation cascade?
A) Cytokines, such as platelet-activating factor (PAF), and tumor necrosis factor- alpha (TNF-α)
B) Thromboxane A, causing platelets to aggregate and consume clotting factors
C) Tissue factor (TF) located in the endothelial layer of blood vessels and subcutaneous tissue
D) Endotoxins from gram-negative and gram-positive bacteria circulating in the bloodstream

Question

Quizplus · Accepted Answer

Direct tissue damage (ischemia and necrosis,surgical manipulation,crushing injury)causes the endothelium to release TF.The common pathway for DIC appears to be excessive and widespread exposure of TF.The other options are not responsible for the activation of the coagulation cascade.

In Disseminated Intravascular Coagulation (DIC),what Activates the Coagulation Cascade