Different studies have tried manipulating leptin activity in mice in different ways. One approach has been to breed mice that lack the ability to produce leptin (Coleman, 1978; Zhang, 1994). Another approach has been to breed mice whose brain lacks functioning leptin receptors (Chen et al., 1996; Halaas et al., 1995). What results were associated with those approaches?
A)In both cases, the mice became underweight.
B)In the first case (mice lacking the ability to produce leptin), the mice became overweight.In the second case (mice lacking the receptors necessary to detect leptin), no significant change in average body weight was observed.
C)In the first case (mice lacking the ability to produce leptin), no significant change in average body weight was observed.In the second case (mice lacking the receptors necessary to detect leptin), the mice became overweight.
D)In both cases, the mice became obese (i.e.overweight).
E)None of these answers accurately reflects the results of those studies.

Question

Quizplus · Accepted Answer

Both approaches to manipulating leptin activity in mice—either by breeding mice that cannot produce leptin or by breeding mice whose brains lack functioning leptin receptors—resulted in the mice becoming obese. This is because leptin is crucial for regulating energy balance and body weight, and its absence or the inability of the body to recognize it leads to uncontrolled weight gain.

Different Studies Have Tried Manipulating Leptin Activity in Mice in Different