Which of the following test results suggests red blood cell (RBC)survival is significantly decreased from the normal of 120 days? A)decreased glycated hemoglobin B)a T_1/2 Cr of 30 days C)normal haptoglobin D)decreased lactic dehydrogenase

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Glycated hemoglobin increases over the life of the red cell as it (the red cell and thus hemoglobin)is continually exposed to glucose in plasma.In hemolytic disease,the red cells have a shortened survival and thus less exposure to glucose,which results in a lower glycated hemoglobin than normal.Haptoglobin is an acute phase protein and may be normal or even increased even in intravascular hemolysis if the patient has concurrent inflammation;thus a normal haptoglobin does not rule out intravascular hemolysis with a shortened RBC survival.Lactic dehydrogenase is released from lysed red cells and increases when RBC survival is shortened.A T₁/₂ Cr of 30 days is normal.

Which of the Following Test Results Suggests Red Blood Cell