Alport syndrome, a dominantly inherited X-linked disorder, is characterized by glomerulonephritis, end-stage kidney disease, and hearing loss. A mother with alport disease, whose father was unaffected, marries an unaffected man. What are the chances that she would give birth to a son with alport syndrome?
A) 0%
B) 25%
C) 50%
D) 75%
E) 100%

Question

Quizplus · Accepted Answer

Since Alport syndrome is an X-linked dominant condition, a mother with the disease has a 50% chance of passing the affected X chromosome to each child. Sons who inherit the affected X chromosome will have the disease, so there's a 50% chance a son will be affected.

Alport Syndrome, a Dominantly Inherited X-Linked Disorder, Is Characterized by Glomerulonephritis