Anticipation is the finding in a genetic disorder that:
A) Mutations in the promoter are more severe than those in exons
B) One is more likely to diagnose genetic disease in additional family members once a family is referred for genetic counseling
C) The severity of phenotype increases, and age of onset decreases as some genetic disorders are passed through families
D) The known variability in a disease phenotype increases once a disorder is described in the literature because of better clinical observation
E) For many complex traits, the likelihood of having an affected child increases the risk of having a second affected child

Question

Quizplus · Accepted Answer

Anticipation refers to the phenomenon where, in certain genetic disorders, the severity of the disorder increases and the age of onset decreases in successive generations. This is often observed in disorders caused by trinucleotide repeat expansions, such as Huntington's disease and myotonic dystrophy.

Anticipation Is the Finding in a Genetic Disorder That