Which of the following is NOT one of the factors that predicts the bioavailability of a drug?
A) The molecular weight is less than 500.
B) The number of hydrogen-bond donors is less than 5.
C) The number of hydrogen-bond acceptors is less than 10.
D) The partition coefficient is less than 5.
E) The structure contains at least two aromatic rings.

Question

Quizplus · Accepted Answer

The presence of at least two aromatic rings is not listed among the common factors predicting the bioavailability of a drug according to Lipinski's Rule of Five. This rule focuses on molecular weight, hydrogen-bond donors, hydrogen-bond acceptors, and partition coefficient to predict oral bioavailability.

Which of the Following Is NOT One of the Factors