Identify the transition state that is involved in the decarboxylation of β-ketoacids.
A) a five-membered cyclic system
B) a six-membered cyclic system
C) a four-membered cyclic system
D) none of these

Question

Quizplus · Accepted Answer

The transition state involved in the decarboxylation of β-ketoacids forms a six-membered cyclic system known as the enolate intermediate. This intermediate is formed by proton transfer from the carboxyl group to the alpha carbon, resulting in the expulsion of CO2 and the formation of a stabilized carbanion. The enolate then undergoes reprotonation to yield the ketone product.

Identify the Transition State That Is Involved in the Decarboxylation