What is the function of anti-inflammatory drugs such as Vioxx and Celebrex?
A) to inhibit the activity of the COX-1 and COX-2 enzymes
B) to inhibit the activity of the COX-1 enzyme
C) to inhibit the activity of the COX-2 enzyme
D) none of these

Question

Quizplus · Accepted Answer

Anti-inflammatory drugs such as Vioxx and Celebrex inhibit the activity of the COX-2 enzyme, which is responsible for producing prostaglandins that cause inflammation, pain, and fever. This helps to reduce inflammation and relieve pain. In contrast, COX-1 produces prostaglandins that protect the stomach lining and promote blood clotting, so inhibiting this enzyme can contribute to gastrointestinal problems and bleeding disorders. Therefore, COX-2 selective inhibitors like Vioxx and Celebrex were developed to maximise therapeutic benefits while minimising side effects. However, it is important to note that Vioxx was withdrawn from the market due to an increased risk of cardiovascular events, and Celebrex carries a black box warning regarding this risk.

What Is the Function of Anti-Inflammatory Drugs Such as Vioxx