Which of the following biomolecules is found in excess in patients with severe combined immune deficiency?
A) dATP
B) tRNA
C) dGTP
D) rRNA

Question

Quizplus · Accepted Answer

Patients with severe combined immune deficiency (SCID) lack functional T and B cells, which are critical for the adaptive immune response. The treatment for SCID typically involves bone marrow transplantation, which requires high-dose chemotherapy to eliminate the patient's existing bone marrow cells. One consequence of this chemotherapy is the release of large amounts of cellular DNA into the bloodstream, which can be metabolized into nucleotides. In particular, dATP (deoxyadenosine triphosphate) can accumulate to toxic levels and cause damage to developing T cells. Therefore, patients with SCID often have elevated levels of dATP in their blood.

Which of the Following Biomolecules Is Found in Excess in Patients