Identify the true statement about presynaptic modulation.
A) Presynaptic modulation affects the amount of neurotransmitter released onto the target.
B) Presynaptic modulation is a direct relationship between two neurons.
C) Presynaptic modulation always reflects facilitation of the synapse.
D) Presynaptic modulation always reflects inhibition of the synapse.

Question

Quizplus · Accepted Answer

Presynaptic modulation refers to the modulation of neurotransmitter release from the presynaptic neuron onto the postsynaptic target. It can be either facilitatory or inhibitory, depending on the neurotransmitter and the specific receptor type involved. Therefore, options C and D are incorrect. Presynaptic modulation can occur via various mechanisms, including feedback from the postsynaptic neuron, activation of autoreceptors on the presynaptic neuron, and modulation by other neurotransmitters or neuromodulators. Therefore, option B is incorrect. Option A is the correct statement about presynaptic modulation as it refers to the effect on neurotransmitter release.

Identify the True Statement About Presynaptic Modulation