Botulinum toxin (Botox) injections are a popular cosmetic treatment because they allow an individual to temporarily reduce visible wrinkles in the skin (usually around the face). What is a probable mechanism of Botox at the neuromuscular junction?
A) Inhibition of muscarinic receptors that cannot then bind to ACh and cause an end-plate potential, causing muscle relaxation.
B) Excitation of ACh vesicles in the pre-synaptic neuron allow for end-plate potentials to be fired and cause muscle tightness due to excess contraction.
C) Inhibition of ACh vesicles in the pre-synaptic neuron prevent an end-plate potential and cause complete muscle relaxation.
D) Excitation of the nicotinic receptors making them extra sensitive to ACh and causing more contractions with less ACh present in the NMJ.

Question

Quizplus · Accepted Answer

Botulinum toxin (Botox) works by inhibiting the release of acetylcholine (ACh) vesicles in the pre-synaptic neuron at the neuromuscular junction. This prevents the generation of an end-plate potential, leading to muscle relaxation by preventing muscle contraction.

Botulinum Toxin (Botox) Injections Are a Popular Cosmetic Treatment Because