The toxin of Vibrio cholerae causes profuse diarrhea because it
A) modifies a G protein involved in regulating salt and water secretion.
B) decreases the cytosolic concentration of calcium ions, making the cells hypotonic.
C) binds with adenylyl cyclase and triggers the formation of cAMP.
D) signals IP₃ to act as a second messenger for the release of calcium.
E) modifies calmodulin and activates a cascade of protein kinases.

Question

Quizplus · Accepted Answer

The toxin of Vibrio cholerae modifies a G protein, which leads to the continuous activation of adenylyl cyclase, resulting in increased levels of cAMP. This causes excessive secretion of water and electrolytes into the intestinal lumen, leading to profuse diarrhea.

The Toxin of Vibrio Cholerae Causes Profuse Diarrhea Because It