What initiates the disassembly of the three major components of the nuclear envelope?
A) phosphorylation of key substrates by mitotic kinases, particularly cyclin B-Cdk1
B) dephosphorylation of key substrates by mitotic phosphatases, particularly cyclin B-Cdk1
C) a cascade begun by ATP synthase
D) phosphorylation of key substrates by mitotic phosphatases, particularly cyclin B-Cdk
E) methylation of key substrates by mitotic kinases, particularly cyclin B-Cdk1
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