Huntington's disease (HD) is a neurodegenerative genetic disorder involving an autosomal dominant mutant allele with high penetrance.If a father's mother had HD, what is the probability that his first child will also have HD?

Question

Quizplus · Accepted Answer

Since Huntington's disease is caused by an autosomal dominant allele, if the father inherited the allele from his mother (who had the disease), he has a 50% chance of passing it on to his child. However, the question does not specify whether the father has the allele, making the probability dependent on this factor.

Huntington's Disease (HD) Is a Neurodegenerative Genetic Disorder Involving an Autosomal