Children with severe combined immune deficiency (SCID) often receive blood products. Any blood products administered to children with SCID who have T-cell deficiencies should be irradiated and cytomegalovirus-negative because of the risk of:
A)Transfusion reaction from lymphocytes and platelets in the donor blood.
B)Transfusion reaction and infection from lymphocytes in the donor blood.
C)Infection and graft-versus-host disease from lymphocytes in the donor blood.
D)Infection and graft-versus-host disease from erythrocytes in the donor blood.

Question

Quizplus · Accepted Answer

Children with severe combined immune deficiency (SCID) are at high risk for infection and graft-versus-host disease (GVHD) due to their compromised immune systems. Irradiation of blood products kills lymphocytes, preventing GVHD, and selecting cytomegalovirus-negative blood reduces the risk of infection. Erythrocytes (red blood cells) do not cause GVHD, which is why the correct answer focuses on lymphocytes in the donor blood.

Children with Severe Combined Immune Deficiency (SCID) Often Receive Blood