The notion of a tit-for-tat strategy applies to a prisoners' dilemma game that is played repeatedly, but it does not apply if the game is played only once.

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In a single iteration of the prisoners' dilemma, there is no opportunity for players to respond to each other's previous actions, which is essential for the tit-for-tat strategy. This strategy relies on the ability to reciprocate the other player's previous move, which only becomes relevant in repeated interactions.

The Notion of a Tit-For-Tat Strategy Applies to a Prisoners