Two proteins interact to form a multimeric complex. When one of the proteins is mutated, there is a substantial loss of functional activity in the multimeric protein. This type of mutation is classified as__________ .
A) null/ amorphic
B) hypomorphic
C) hypermorphic
D) neomorphic
E) dominant negative

Question

Quizplus · Accepted Answer

Dominant negative mutations occur when a mutant protein interferes with the function of the wild-type protein within the same multimeric complex, leading to a substantial loss of functional activity. This is because the mutant protein can still integrate into the complex but impairs its function, rather than simply reducing the amount of functional protein (as in a null or hypomorphic mutation) or altering the function in a way that increases activity (hypermorphic) or creates a new function (neomorphic).

Two Proteins Interact to Form a Multimeric Complex