Which of the Following Statements Is True Concerning the Bioavailability

Which of the following statements is true concerning the bioavailability of chemical compounds related to drug misuse abuse?

A) There is little known about drug distribution patterns in overdose situations.
B) The main site of biotransformation is the pancreas.
C) The effects of any compound are the same in animals as in humans.
D) The method of administration for a compound does not matter in pharmacokinetics.