Within a differentiated B cell, the rearrangement of DNA sequences between variable regions and joining regions is accomplished by a(n)________.
A) RNA polymerase
B) reverse transcriptase
C) telomerase
D) recombinase

Question

Quizplus · Accepted Answer

The process described in the question is known as V(D)J recombination, and it requires the action of a recombinase enzyme complex. This complex includes proteins such as RAG-1 and RAG-2, which mediate the rearrangement of DNA segments between variable (V), diversity (D), and joining (J) regions in the immunoglobulin genes of B cells. RNA polymerase, reverse transcriptase, and telomerase do not play roles in this process.

Within a Differentiated B Cell, the Rearrangement of DNA Sequences