Unequal crossing over during prophase I can result in one sister chromosome with a deletion and another with a duplication. A mutated form of hemoglobin, so-called hemoglobin Lepore, exists in the human population. Hemoglobin Lepore has a deleted series of amino acids. If this mutated form was caused by unequal crossing over, what would be an expected consequence?
A) There should also be persons whose hemoglobin contains two copies of the series of amino acids that is deleted in hemoglobin Lepore.
B) Each of the genes in the hemoglobin gene family must show the same deletion.
C) The deleted gene must have undergone exon shuffling.
D) The deleted region must be located in a different area of the individual's genome.

Question

Quizplus · Accepted Answer

Unequal crossing over can result in one sister chromosome having a deletion and another with a duplication. Therefore, if hemoglobin Lepore was caused by unequal crossing over, it is expected that some individuals may have two copies of the deleted series of amino acids in their hemoglobin instead of just one, as in the case of hemoglobin Lepore.

Unequal Crossing Over During Prophase I Can Result in One