Why is sequencing of eukaryotic genomes more difficult than sequencing genomes of bacteria or archaea?
A) It is due to the large size of eukaryotic proteins.
B) Eukaryotic genomes contain sequences for hard-to-find proteins.
C) There is a high proportion of G-C base pairs in eukaryotic DNA, which makes sequencing difficult to complete.
D) The large size of eukaryotic genomes and the large amount of eukaryotic repetitive DNA make sequencing difficult.

Question

Quizplus · Accepted Answer

The large size of eukaryotic genomes, which can be several orders of magnitude larger than bacterial or archaeal genomes, and the presence of large amounts of repetitive DNA sequences make sequencing more difficult and time-consuming. Additionally, eukaryotic genomes often have complex regulatory elements and alternative splicing events that can increase the complexity of genome assembly and annotation.

Why Is Sequencing of Eukaryotic Genomes More Difficult Than Sequencing