Which of the following statements supports the one gene-one enzyme hypothesis?
A) A mutation in a single gene can result in a defective protein.
B) Alkaptonuria results when individuals lack multiple enzymes involved in the catalysis of homogentisic acid.
C) Sickle-cell anemia results in normal hemoglobin.
D) Multiple antibody genes can code for different related proteins, depending on the splicing that takes place post-transcriptionally.

Question

Quizplus · Accepted Answer

The one gene-one enzyme hypothesis proposes that each gene codes for a single enzyme, and a mutation in a single gene can result in a defective protein. This supports the hypothesis that a single gene is responsible for producing a single enzyme.

Choice B is not the best answer because alkaptonuria is caused by a deficiency in a single enzyme, homogentisate dioxygenase, rather than multiple enzymes.

Choice C is incorrect because sickle-cell anemia results in the production of an abnormal hemoglobin protein due to a single amino acid substitution, not a total lack of hemoglobin.

Choice D is not the best answer since it describes the splicing of multiple genes to produce different proteins, which is not directly related to the one gene-one enzyme hypothesis.

Which of the Following Statements Supports the One Gene-One Enzyme