Abnormal chromosomes are frequently found in malignant tumors. Errors such as translocations may place a gene in close proximity to different control regions. Which of the following events might then occur to make the cancer worse?
A) an increase in nondisjunction
B) expression of inappropriate gene products
C) a decrease in mitotic frequency
D) failure of the cancer cells to multiply

Question

Quizplus · Accepted Answer

When a gene is placed close to different control regions due to chromosomal abnormalities, it may start expressing inappropriate gene products which could make the cancer worse. A decrease in mitotic frequency or failure of the cancer cells to multiply may actually be beneficial in terms of controlling the growth of cancer cells. An increase in nondisjunction may further increase the chromosomal abnormalities, but it does not directly affect the expression of inappropriate gene products.

Abnormal Chromosomes Are Frequently Found in Malignant Tumors