Which of the following statements describes an example of cooperativity associated with enzyme regulation?
A) binding of the end product of a metabolic pathway to the first enzyme in the pathway to inhibit the enzyme
B) one enzyme in a metabolic pathway passing its product to act as a substrate for the next enzyme in the pathway
C) binding a substrate to one subunit of a tetramer stimulates faster binding of substrate to each of the other three subunits
D) binding of an ATP molecule along with another substrate molecule in the active site of the enzyme

Question

Quizplus · Accepted Answer

Cooperativity refers to the phenomenon where the binding of a molecule (such as a substrate or inhibitor) to one site on an enzyme affects the binding or activity of a different site on the same enzyme. In this case, binding of a substrate to one subunit of a tetramer (a four-subunit enzyme) stimulates faster binding of substrate to each of the other three subunits. This is an example of positive cooperativity, where the binding of one substrate molecule increases the affinity of the other subunits for substrate, leading to an overall increase in enzyme activity.

Which of the Following Statements Describes an Example of Cooperativity