Ovaries decrease in size with age and are less responsive to gonadotropins, which causes a decrease in estrogen secretion leading to increased susceptibility to osteoporosis.

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As women age, the size of their ovaries and their response to gonadotropins decrease, leading to a decline in estrogen secretion. This decrease in estrogen can contribute to an increased risk of osteoporosis.

Ovaries Decrease in Size with Age and Are Less Responsive