During the development of lymphocytes, some pre-T and pre-B cells survive and develop into cells capable of an immune response; this is referred to as ________ selection. However, some cells are suppressed from responding to self antigens; this is referred to as ________ selection.
A) negative; positive
B) neutral; negative
C) negative; neutral
D) neutral; positive
E) positive; negative

Question

Quizplus · Accepted Answer

During the development of lymphocytes, cells that can respond to foreign antigens are positively selected to mature and function in the immune response. Conversely, cells that react strongly to self antigens are negatively selected, meaning they are either destroyed or become non-reactive, to prevent autoimmune reactions.

During the Development of Lymphocytes, Some Pre-T and Pre-B Cells