How is the development of autoimmunity normally prevented?
A) Regulatory T cells suppress autoimmune responses.
B) T lymphocytes require a specific set of cytokine signals to become activated.
C) Clonal deletion of T cells, lack of necessary cytokine signals, and regulatory T cell suppression prevent activation of autoreactive T cells.
D) Clonal deletion of T cells and regulatory T cell suppression prevent autoreactive T cell activation.
E) T lymphocytes that respond to autoantigens in the thymus undergo clonal deletion.

Question

Quizplus · Accepted Answer

The development of autoimmunity is normally prevented by a combination of mechanisms: clonal deletion of T cells that recognize self-antigens, lack of necessary cytokine signals for activation, and suppression by regulatory T cells.

How Is the Development of Autoimmunity Normally Prevented