What would be the consequence of a mutation in the gene that encodes sigma factor for bacterial transcription?
A) The initiation of transcription may begin at random points of the DNA template.
B) The RNA polymerase may not be released from the DNA template.
C) Transcription may be delayed indefinitely, which may kill the cell.
D) The RNA transcript may not be able to dissociate from the DNA template.
E) The transcription may end prematurely, resulting in shorter mRNA transcript.

Question

Quizplus · Accepted Answer

Sigma factors are responsible for the initiation of transcription by guiding RNA polymerase to specific promoter regions. A mutation could cause RNA polymerase to bind non-specifically, leading to random initiation sites.

What Would Be the Consequence of a Mutation in the Gene