Which Reasoning Is a Plausible Explanation for Why It May

Which reasoning is a plausible explanation for why it may be difficult to treat infections that arise from tooth decay?

A) Biofilm bacteria that cause tooth decay begin to produce endospores as a means to deter effects of antibiotics.
B) Binary fission in biofilm bacteria that cause tooth decay begins to decrease as the biofilm community becomes more complex, thereby producing fewer bacterial cells for antibiotics to penetrate.
C) As the biofilm that causes tooth decay becomes larger, its structure makes it difficult for antibiotics to break through bacterial cell walls.
D) Bacteria of the biofilm that cause tooth decay form a symbiotic relationship with the antibiotics and therefore diminish antibiotic effectiveness.