Why might some blood banking facilities prefer the use of monospecific IgG over polyspecifiic antihuman globulin (AHG) in their antibody screens?
A) Interference from naturally occurring warm antibodies in patient serum is reduced.
B) Interference from naturally occurring cold antibodies in patient serum is reduced.
C) There is more IgG in monospecific antisera than in polyspecific reagents.
D) Monospecific IgG has been standardized.

Question

Quizplus · Accepted Answer

Monospecific IgG is preferred because it reduces interference from naturally occurring cold antibodies, which are typically IgM and react at lower temperatures. Polyspecific AHG can detect both IgG and complement, leading to potential false positives from cold antibodies.

Why Might Some Blood Banking Facilities Prefer the Use of Monospecific