If the repeated exposure to a drug increases the activity of the CYP450 enzyme that is responsible for metabolizing that drug, then future doses of the drug will be less effective than the first doses. What is this an example of?
A) Drug disposition tolerance
B) Behavioural tolerance
C) An active metabolite
D) A prodrug

Question

Quizplus · Accepted Answer

This is an example of drug disposition tolerance, which occurs when changes in the body's ability to metabolize a drug lead to a decrease in the drug's effectiveness over time. In this case, the increased activity of the CYP450 enzyme, responsible for drug metabolism, results in the drug being metabolized more quickly, reducing its effectiveness with repeated use.

If the Repeated Exposure to a Drug Increases the Activity