Which piece of evidence, if found, would weaken the dopamine hypothesis the most?
A) a study showing that when people are given excess doses of L-dopa, they subsequently develop symptoms of schizophrenia
B) a study showing that other drugs that increase dopamine activity, such as amphetamines, also produce symptoms of schizophrenia
C) a study showing that drugs that bind to receptors other than dopamine reduce or eliminate the symptoms of schizophrenia
D) a study showing that phenothiazines are more effective than second-generation antipsychotic drugs in reducing the symptoms of schizophrenia

Question

Quizplus · Accepted Answer

The dopamine hypothesis of schizophrenia posits that the disorder is linked to increased dopamine activity. Thus, evidence showing that drugs targeting non-dopamine receptors can also reduce or eliminate schizophrenia symptoms would challenge the centrality of dopamine in the disorder, weakening the hypothesis.

Which Piece of Evidence, If Found, Would Weaken the Dopamine