The primary mechanism of tolerance to THC is a(n)_____ receptors.
A)downregulation of CB1
B)downregulation of CB2
C)upregulation of CB1
D)upegulation of CB2

Question

Quizplus · Accepted Answer

Tolerance to THC occurs through downregulation of CB1 receptors, which means that the number of CB1 receptors decrease in response to prolonged exposure to THC. This leads to a reduced response to THC, resulting in a need for higher doses to achieve the same effect, and ultimately leads to tolerance. Downregulation of CB2 receptors has not been shown to contribute significantly to THC tolerance. Upregulation of either receptor is not a mechanism of tolerance.

The Primary Mechanism of Tolerance to THC Is A(n)_____ Receptors