A mutation that results in a single amino acid substitution in the active site of an enzyme may have which of the following consequences?
A)It may alter the ability of a noncompetitive inhibitor to bind to the enzyme.
B)It may alter the ability of an allosteric regulator to effect enzyme activity.
C)It may change the substrate specificity of the enzyme.
D)It may change the ∆G for the original reaction catalyzed by the enzyme.

Question

Quizplus · Accepted Answer

A single amino acid substitution in the active site of an enzyme can change the shape or charge properties of the active site, potentially altering the enzyme's substrate specificity. This is because the precise interactions between an enzyme and its substrate are critical for binding and catalysis. Changes in these interactions can affect how well the enzyme binds to its substrate or even alter the range of substrates it can bind.

A Mutation That Results in a Single Amino Acid Substitution