The free-energy change for the hydrolysis of ATP to ADP + ℗_i,under standard conditions (1 M concentration of both reactants and products)is -7.3 kcal/mol.However,in the cytoplasm of the cell,the free-energy change is about -13 kcal/mol.Based on this observation,what would you predict the free-energy change for the reverse reaction (formation of ATP from ADP and ℗_i)would be under cellular conditions? A)about +7.3 kcal/mol B)less than +7.3 kcal/mol C)about +13 kcal/mol D)about +26 kcal/mol

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Quizplus · Accepted Answer

The free-energy change for a reaction is the negative of that for the reverse reaction. Since the hydrolysis of ATP in the cell has a ΔG of about -13 kcal/mol, the reverse reaction (formation of ATP) would have a ΔG of about +13 kcal/mol under the same conditions.

The Free-Energy Change for the Hydrolysis of ATP to ADP