Which kind of metabolic poison would most directly interfere with glycolysis? A)an agent that reacts with oxygen and depletes its concentration in the cell B)an agent that binds to pyruvate and inactivates it C)an agent that closely mimics the structure of glucose but is not metabolized D)an agent that reacts with NADH and oxidizes it to NAD⁺ E)an agent that blocks the passage of electrons along the electron transport chain

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Glycolysis involves the breakdown of glucose into pyruvate in a series of enzymatic reactions. If an agent closely mimics the structure of glucose but is not metabolized (choice C), it can compete with glucose for binding to enzymes involved in glycolysis and effectively block the pathway. Choices A, B, D, and E do not directly interfere with glycolysis. Choice A would interfere with aerobic respiration, choice B would specifically affect the conversion of pyruvate to acetyl-CoA, choice D would affect the availability of NADH for later stages of respiration, and choice E would affect oxidative phosphorylation.

Which Kind of Metabolic Poison Would Most Directly Interfere with Glycolysis