A mutation results in the change of Ser to Asp in the substrate binding pocket of chymotrypsin.Most likely,the mutant enzyme will
A) no longer catalyze the hydrolysis of a peptide bond because Asp cannot facilitate the nucleophilic attack.
B) no longer catalyze the hydrolysis of a peptide bond because Asp is unable to be deprotonated by His57.
C) preferentially hydrolyze substrates containing phenylalanine.
D) preferentially hydrolyze substrates containing lysine.

Question

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The Answer of A mutation results in the change of Ser to Asp in the substrate binding pocket of chymotrypsin.Most likely,the mutant enzyme will
A) no longer catalyze the hydrolysis of a peptide bond because Asp cannot facilitate the nucleophilic attack.
B) no longer catalyze the hydrolysis of a peptide bond because Asp is unable to be deprotonated by His57.
C) preferentially hydrolyze substrates containing phenylalanine.
D) preferentially hydrolyze substrates containing lysine.

A Mutation Results in the Change of Ser to Asp