When the citrate cycle is inhibited, which two metabolites are exported to the cytosol for fatty acid and cholesterol synthesis?
A) "malate and succinyl-CoA"
B) "succinyl-CoA and $\alpha$-ketoglutarate"
C) "$\alpha$-ketoglutarate and citrate"
D) "citrate and malate"

Question

Quizplus · Accepted Answer

Citrate and malate are the two metabolites exported to the cytosol for fatty acid and cholesterol synthesis when the citrate cycle is inhibited. Citrate is used for acetyl-CoA production, which is a precursor for these syntheses, and malate can be converted into pyruvate or back into acetyl-CoA, providing NADPH needed for the biosynthetic processes.

When the Citrate Cycle Is Inhibited, Which Two Metabolites Are α\alphaα

When the Citrate Cycle Is Inhibited, Which Two Metabolites Are $\alpha$