A high NADH to NAD⁺ratio would inhibit which enzyme in the citrate cycle? A) succinate dehydrogenase B) succinyl-CoA synthetase C) aconitase D) isocitrate dehydrogenase

Question

Quizplus · Accepted Answer

A high NADH to NADH+ ratio indicates high energy levels within the cell and therefore a decreased need for energy production through the citrate cycle. Isocitrate dehydrogenase is the rate-limiting enzyme in the citrate cycle and is inhibited by high levels of NADH, which would result in the accumulation of isocitrate and potentially downstream metabolites such as α-ketoglutarate. Therefore, option D is the best choice.

A High NADH to NAD+ ratio Would Inhibit Which Enzyme

A High NADH to NAD⁺ratio Would Inhibit Which Enzyme